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KMID : 0043320070300111387
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Archives of Pharmacal Research
2007 Volume.30 No. 11 p.1387 ~ p.1391
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Two New Triterpene Glycosides from the Vietnamese Sea Cucumber Holothuria scabra
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Dang Nguyen Hai
Thanh Nguyen Van
Keum Phan Van
Huong Le Mai
Minh Chau Van
Kim Young-Ho
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Abstract
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Two new triterpene glycosides, namely holothurin A3 (1) and A4 (2) were isolated from the methanol extract of the sea cucumber, Holothuria scabra, with their structures elucidated from the spectroscopic evidence (1D NMR, 2D NMR, ESI-MS and HRESI-MS). Compounds 1 and 2 were found to be strongly cytotoxic to both cancer cell lines, KB and Hep-G2, with 50% inhibitory concentrations (IC50) of 0.87 and 0.32 킽/mL (for compound 1) and of 1.12 and 0.57 킽/mL (for compound 2), respectively
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KEYWORD
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Sea cucumber, Holothuria scabra, Triterpene glycoside, Holothurin A3, Holothurin A4
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